![]() ![]() ![]() Avoiding beta-lactam antibiotics leads to suboptimal treatment with less effective antibiotics (e.g.Nafcillin or cefazolin are more effective against methicillin-sensitive Staph aureus (MSSA) than vancomycin.Beta-lactam antibiotics are often the most effective treatment.These treatments may increase the risk for antimicrobial resistance and adverse events, including * * Unnecessary withholding of penicillins or cephalosporins in patients who are labeled as allergic on the basis of history alone, carries important risks for individual and public health, as it is associated with increased use of second-line or broader-coverage antimicrobial treatments (e.g. Almost 80% of patients who are positive for a penicillin skin test are no longer sensitive when re-challenged after a period of 10 years *.Ĭlinical implications of unverified antibiotic allergy labels IgE-mediated reactions to beta-lactams can wane over time.The original reaction (even if it was an immunological reaction), might not recur with re-challenge.The original reaction might not have been an allergy (there could be intolerance, a viral exanthem, or a drug-infection interaction) *.they tolerate penicillin and related drugs) *. However most of these patients labeled with penicillin or cephalosporins allergy are not allergic (i.e. In this post an approach to determining whether a patient with reported penicillin allergy can be treated with penicillins or related beta-lactam antibiotics is reviewed.Īpproximately 10% of the population carry a label of penicillin or beta-lactam allergy. This mislabeling carries important risks for individual and public health. The vast majority of patients labelled as penicillin or beta-lactam allergic are not deemed truly allergic when appropriately stratified for risk, tested, and re-challenged. Beta-lactam allergy and cross-reactivity. ![]()
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